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Seventy-eight percent were diagnosed in the first decade, 15% in the second decade, and 7% in the third decade.

There is no experience with Gleevec treatment in children under 1 year of age.

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If this highly active enzyme could be suppressed, CML might be treatable.

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Interactions may occur between imatinib and inhibitors or inducers of CYP3A4 and CYP3A5 enzymes leading to changes in the plasma concentration of imatinib as well as that of co-administered drugs ().

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Jane Siegel, professor of pediatrics and an infectiousdisease specialist at the University of Texas Southwestern Medical Center at Dallas, said: There have been studies of this type in individual institutions.

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